JKMC | VOL. 6 | NO. 2 | ISSUE 20 | APR-JUN, 2017

Ultra-sonographic image of ovarian mass and increased CA 19-9 levels as a pre-operative diagnostic predictor of mature cystic teratoma of ovary
Malla S, Fan J, Vaidya T


Abstract:
Background: Tooth brushing with toothpaste is the most widely practiced form of oral hygiene. Toothpaste aids to improve oral hygiene and effective plaque removal. A wide range of chemicals, mainly antimicrobial agents, have been added to toothpastes which kill microorganisms by disrupting their cell walls and inhibiting their enzymatic activity.

Objectives: The aim of the study was to determine the antimicrobial activity of toothpastes.

Methods: A prospective study on 65 patients at First Affiliated Hospital, Guangxi Medical University, China within the period of one year. Patients underwent pelvic examination, ultra-sonograph and evaluation of serum level of CA 19-9, CA 125, CEA, AFP and SCCA prior to surgery. Following the surgery,samples were subjected for histo-pathological analysis where confirmatory diagnosis of Mature Cystic teratoma of ovary was established. Serum CA 19-9 was then re-analyzed following surgical removal of the tumor.

Results: Mean age of patients with mature Cystic teratoma was 32.5 plus minus 12.1 years (range 15-71). Mean tumor diameter was 5.8 plus minus 2.4 cm (range 2.3-12.2). Serum level of CA 19-9 was the only tumor marker with a mean serum level (49.9 plus minus 73.4 IU/ml) above the cut-off value and its elevated rate was 30.76 %. Rate of bilateral tumors was 16.9%. The tumor size was significantly higher in patients with elevated CA 19-9 than those with normal CA 19-9. There was significant difference in the serum level of CA 19-9 before and after the surgery (p<0.002) in patients with elevated level of CA 19-9 pre-operatively. 

Conclusion: Among all subjects who underwent pelvic ultrasonography imaging and analysis of tumor markers (CA 19-9, CA 125, CEA, AFP and SCCA) prior to surgery, serum level of CA 19-9 has the highest positivity rate in mature cystic teratomas of ovary and its level decreases following surgical removal.


Keyword : CA 19-9, Mature cystic teratoma ovary, Ultra-sonography