@article{Sherchan_2021, title={Antibiotic susceptibility pattern and risk factors associated with Acinetobacter and Pseudomonas infection at a tertiary care hospital }, volume={10}, url={https://jkmc.com.np/ojs3/index.php/journal/article/view/1057}, abstractNote={<p><strong>Background:</strong> Infection due to <em>Acinetobacter</em> spp. and <em>Pseudomonas aeruginosa</em> is a major worldwide concern these days. Antibiotic resistance and predisposing factors among the patients for acquiring such infection is a major challenge globally and in Nepal.</p> <p><strong>Objectives:</strong> To determine antimicrobial susceptibility pattern of <em>Acinetobacter</em> spp<em>.</em> and <em>Pseudomonas aeruginosa</em> isolates along with predisposing factors.</p> <p><strong>Methods:</strong> A total of 9,705 clinical samples were processed in this analytical cross-sectional study from December 2019 to November 2020. Antibiotic susceptibility pattern was determined following Clinical Laboratory Standard Institute guidelines. Patients’ information was obtained after informed consent.</p> <p><strong>Results:</strong> <em>Acinetobacter </em>spp. and <em>Pseudomonas aeruginosa</em> isolates were 92 (0.95%). Fifty-three (57.61%) samples were respiratory samples. Thirteen (20%) <em>Pseudomonas aeruginosa</em> and 18 (66.67%) <em>Acinetobacter</em> spp. were multidrug-resistant (MDR). Eight (12.31%) <em>Pseudomonas aeruginosa</em> strains and 13 (48.15%) <em>Acinetobacter</em> spp. strains were sensitive only to Colistin.   Twenty-two (95.65%) prolonged hospital stayers had MDR bacteria compared to only nine (13.04%) non-prolonged hospital stayers (p-value <0.001). Sixteen (94.12%) of diabetic patients had MDR bacteria isolates in comparison to only 15 (20%) of non-diabetic patients (p-value <0.001). Thirty-one (33.69%) were elderly patients (age ?65 years) and 61 (66.31%) were of age less than 65 years old. Seventeen (54.84%) of elderly patients had MDR isolates whereas only 14 (22.95%) of patients who are not elderly had MDR isolates (p-value =0.0047).</p> <p><strong>Conclusion: </strong><em>Acinetobacter </em>spp. and <em>Pseudomonas aeruginosa</em> strain were isolated from various samples. For effective treatment of infection by such organisms detailed microbiological diagnosis and drug susceptibility testing is needed along with identification of predisposing factors.</p>}, number={1}, journal={Journal of Kathmandu Medical College}, author={Sherchan, Jatan Bahadur}, year={2021}, month={Aug.} }