Keywords
Nepal
syndrome
Coronavirus disease 2019
Severe acute respiratory syndrome coronavirus-2
How to Cite
Abstract
Background: Coronavirus disease 2019 (COVID-19) causes mild to severe respiratory illness and is associated with ICU admission and mortality. Since data regarding clinical profile of COVID-19 patients in Nepal is still lacking, it is important to study clinical behaviour of COVID-19 in Nepal. In this study the demographic profile, clinical features, lab parameters, and outcomes in hospitalised COVID-19 patients in a tertiary care hospital are reported.
Objective: To assess the clinical profile in terms of clinical symptoms, laboratory parameters, and outcome of COVID-19 admitted patients in a tertiary care hospital.
Methods: This is a descriptive cross-sectional study conducted at KMCTH, from June 1, 2021 to July 31, 2021 after taking ethical clearance from institutional review committee. All patients infected with COVID-19 admitted in this hospital, from June 1, 2021 to July 31, 2021 were included by convenience sampling. Data were collected, and entry and analysis were done in Microsoft Excel Sheet 2007.
Results: During the study period, 245 COVID-19 patients were admitted and were included in the study. The median age of the patients was 55 years, the mean age was 55 ± 17 years, and 139 (56.74%) were male. The common presenting complaints were cough in 180 (73.47%) followed by fever in 176 (71.84%) patients. Most common comorbidity found was hypertension in 89 (36.33%), followed by diabetes in 50 (20.44%).
Conclusion: In this single-centred study, the characteristic features included presence of comorbidities, higher level of inflammatory markers, and high mortality rate in severe to critical hospitalised COVID-19 patients.
References
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W; China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 Feb 20;382(8):727-733. [PubMed | Full Text | DOI]
Ciotti M, Angeletti S, Minieri M, Giovannetti M, Benvenuto D, Pascarella S, Sagnelli C, Bianchi M, Bernardini S, Ciccozzi M. COVID-19 Outbreak: An Overview. Chemotherapy. 2019;64(5-6):215-223. [PubMed | Full Text | DOI]
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. [ PubMed | Full Text | DOI]
World Health Organization. WHO Director-General’s Opening Remarks at the Media Briefing on COVID-19 -11 March 2020 [Internet]. [cited 2022 January 29]. Available from: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020/. [Full Text]
World Health Organization. WHO Coronavirus (COVID-19) Dashboard [Internet]. [cited 2022 January 29]. Available from: https://covid19.who.int/. [Full Text]
World Health Organization. WHO Coronavirus (COVID-19) Dashboard [Internet]. [cited 2022 January 29]. Available from: https://covid19.who.int/region/searo/country/np/. [Full Text]
Soni SL, Kajal K, Yaddanapudi LN, Malhotra P, Puri GD, Bhalla A, Singh MP, Sehgal IS, Koushal V, Varma N, Biswal M, Lakshmi PVM, Sharma S, Suri V, Deepy Z, Ram S, Yadav J, Pandey N, Sharma P, Malik N, Goyal K, Mehra A, Sahoo S, Mohindra R, Francis J, Bhargava M, Singla K, Babu P, Verma A, Khaire NS, Guru RR. Demographic & clinical profile of patients with COVID-19 at a tertiary care hospital in north India. Indian J Med Res. 2021 Jan & Feb;153(1 & 2):115-125. [PubMed | Full Text | DOI]
Mohan A, Tiwari P, Bhatnagar S, Patel A, Maurya A, Dar L, Pahuja S, Garg R, Gupta N, Sahoo B, Gupta R, Meena VP, Vig S, Pandit A, Mittal S, Madan K, Hadda V, Dwivedi T, Choudhary A, Brijwal M, Soneja M, Guleria R, Ratre B, Kumar B, Bhopale S, Panda S, Singh AR, Singh S, Wundavalli L. Clinico-demographic profile & hospital outcomes of COVID-19 patients admitted at a tertiary care centre in north India. Indian J Med Res. 2020 Jul & Aug;152(1 & 2):61-69. [PubMed | Full Text | DOI]
Bhandari S, Bhargava A, Sharma S, Keshwani P, Sharma R, Banerjee S. Clinical Profile of Covid-19 Infected Patients Admitted in a Tertiary Care Hospital in North India. J Assoc Physicians India. 2020 May;68(5):13-17. [PubMed | Full Text]
Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, Satlin MJ, Campion TR Jr, Nahid M, Ringel JB, Hoffman KL, Alshak MN, Li HA, Wehmeyer GT, Rajan M, Reshetnyak E, Hupert N, Horn EM, Martinez FJ, Gulick RM, Safford MM. Clinical Characteristics of Covid-19 in New York City. N Engl J Med. 2020 Jun 11;382(24):2372-2374. [PubMed | Full Text | DOI]
Yue H, Bai X, Wang J, Yu Q, Liu W, Pu J, Wang X, Hu J, Xu D, Li X, Kang N, Li L, Lu W, Feng T, Ding L, Li X, Qi X; Gansu Provincial Medical Treatment Expert Group of COVID-19. Clinical characteristics of coronavirus disease 2019 in Gansu province, China. Ann Palliat Med. 2020 Jul;9(4):1404-1412. [PubMed | Full Text | DOI]
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061-1069. [PubMed | Full Text | DOI]
Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, Li P, Zhou Y, Lin YF, Duan Q, Luo G, Fan S, Lu Y, Feng A, Zhan Y, Liang B, Cai W, Zhang L, Du X, Li L, Shu Y, Zou H. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J Infect. 2020 Jun;80(6):656-665. [PubMed | Full Text | DOI]
Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R, Iotti G, Latronico N, Lorini L, Merler S, Natalini G, Piatti A, Ranieri MV, Scandroglio AM, Storti E, Cecconi M, Pesenti A; COVID-19 Lombardy ICU Network. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020 Apr 28;323(16):1574-1581. [PubMed | Full Text | DOI]
World Health Organization. Living guidance for clinical management of COVID-19 [Internet]. [cited 2022 January 29]. Available from: https://www.who.int/publications/i/item/W