Abstract
Background: Antibiotic abuse has drawn the attention of public health experts, stakeholders, and medical science due to the substantial economic loss that it causes to individuals and nation.
Objectives: To assess the knowledge, attitude, and behaviour on antibiotic abuse among undergraduate level students of Pokhara, Nepal.
Methods: This analytical cross-sectional study was conducted after ethical clearance in 361 undergraduate level students of Pokhara, Nepal from 2022 November to 2023 January. Convenience sampling technique was utilised for data collection. Data were analysed primarily by Chi-square test to find the associated factors using SPSS v.21.
Results: A total of 361 respondents participated, and 61.77% were female. Most of the respondents (67.31%) were from health sciences, while 32.68% of the respondent was of non-health sciences. The mean age of the respondents was 20.97 ± 1.56 years. More than half of the respondents had inadequate knowledge and unfavourable attitude towards antibiotics while the prevalence of self-medication was found to be 72.6%.
Conclusion: This study recommends for further large-scale research to understand the current state of antibiotic use and misuse among general population. Self-medication rate was high regardless of perceived knowledge and positive attitude. So, this study urges for the need of behavioural interventions that aims at raising awareness and establishing effective use of antibiotics.
References
Harbarth S, Samore MH. Antimicrobial resistance determinants and future control. Emerg Infect Dis. 2005 Jun;11(6):794-801. [PubMed | Full Text | DOI]
Islam S, Aldstadt J, Aga D. Global antimicrobial resistance: A complex and dire threat with few definite answers. Tropical Medicine and International Health. 2019;24(6):658-62. [PubMed | Full Text | DOI]
Ayukekbong JA, Ntemgwa M, Atabe AN. The threat of antimicrobial resistance in developing countries: Causes and control strategies. Antimicrob Resist Infect Control.2017 May 15;6(1):47. [PubMed | Full Text | DOI]
Okeke, I.N. Poverty and root causes of resistance in developing countries. In Antimicrobial Resistance in Developing Countries; Springer: Berlin, Germany, 2009:27-35. [Full Text]
WHO. WHO’s first global report on antibiotic resistance reveals serious, worldwide threat to public health; WHO News: Geneva, Switzerland, 2014. 6. Sawair, F.A.; Baqain, Z.H.; Karaky, A.A.; Eid, R.A. Assessment of self-medication of antibiotics in a Jordanian population. Med. Princ. Pract. 2009;18:21- 5. [PubMed | Full Text | DOI]
World Health Organization. Antimicrobial resistance: Global report on surveillance; WHO: Geneva, Switzerland, 2014. [Full Text]
Nayak, S. Rana, M. Mayya, S. Antibiotics to cure or harm: Concept of antibiotic resistance among health professional students in Nepal. Int. J. Med. Sci. Public Health 2016;5:2512-7. [Full Text]
Sah, A.K. Self-medication with antibiotics among nursing students of Nepal. IJPSR 2016, 7, 427-30 [Full Text]
Seid MA, Hussen MS. Knowledge and attitude towards antimicrobial resistance among final year undergraduate paramedical students at University of Gondar, Ethiopia.BMC Infect Dis. 2018 Dec;18(1):312. [PubMed | Full Text | DOI]
Lim KK, Teh CC. A cross sectional study of public knowledge and attitude towards antibiotics in Putrajaya, Malaysia. South Med Rev. 2012 Dec 27;5(2):26- 33. [PubMed | Full Text]
McNulty CAM, Boyle P, Nichols T, Clappison P, Davey P. Donot wear me out—the public’s knowledge of and attitudes to antibiotic use. J Antimicrob Chemother. 2007 Apr 1;59(4):727-38. [Full Text]
Shehadeh M, Suaifan G, Darwish RM, Wazaify M, Zaru L, Alja’fari S. Knowledge, attitudes and behaviour regarding antibiotics use and misuse among adults in the community of Jordan. A pilot study. Saudi Pharmaceutical Journal. 2012 Apr;20(2):125-33. [PubMed | Full Text | DOI]
Arshad MS, Rasool MF, Ijaz M, Hussain A. Evaluation of Antibiotic Use Behaviour in Cold and Flu amongst the Students of Bahauddin Zakariya University Multan, Pakistan. Pak J Pharm. 2010; 23(2):15-22. [Full Text]
Scaioli G, Gualano MR, Gili R, Masucci S, Bert F, Siliquini R. Antibiotic use: knowledge, attitudes and practicesamong health profession students in Italy Giacomo Scaioli. Eur J Public Health. 2014 Oct 1;24(16)1-131. [Full Text]
Al-Shibani N, Hamed A, Labban N, Al-Kattan R, Al-Otaibi H, Alfadda S. Knowledge, attitude and practice of antibiotic use and misuse among adults in Riyadh, Saudi Arabia. Saudi Med J. 2017 Oct;38(10):1038-44. [PubMed | Full Text | DOI]
Tina LK, James HP, Susan KT. Knowledge, beliefs, and use of prescribed antibiotic medications among low- socioeconomic African Americans. Journal of the National Medical Association. 1996;88(5):289-94. [PubMed | Full Text]
Marzan M, Islam DZ, Lugova H, Krishnapillai A, Haque M, Islam S. Knowledge, attitudes, and practices of antimicrobial uses and resistance among public university students in Bangladesh. Infect Drug Resist. 2021 Feb 11;14:519-33. [PubMed | Full Text | DOI]
Nayak, S. Rana, M. Mayya, S. Antibiotics to cure or harm: Concept of antibiotic resistance among health professional students in Nepal. Int. J. Med. Sci. Public Health 2016, 5, 2512–2517. [Full Text]
Sah, AK. Self-medication with antibiotics among nursing students of Nepal. IJPSR 2016;7:427–30. [Full Text]
McNulty CAM, Boyle P, Nichols T, Clappison P, Davey P. Donot wear me out—the public’s knowledge of and attitudes to antibiotic use. J Antimicrob Chemother. 2007 Apr 1;59(4):727-38. [Full Text]
Awad AI, Aboud EA. Knowledge, Attitude and Practice towards Antibiotic Use among the Public in Kuwait. PLoS One. 2015 Feb 12;10(2):e0117910. [PubMed | Full Text | DOI]
Bijani M, Hamidizadeh S, Rostami K, Haghshenas A, Mohammadi F, Ghasemi A, et al. Evaluation of the effect of clinical scenario-based educational workshop and reflection on the knowledge and attitude of head nurses and clinical supervisors toward in the Brain death and organ donation. Electron J Gen Med. 2020 Apr 5;17(5):em233. [Full Text | DOI]
Mohanna M. Self-medication with antibiotic in children in Sana’a City, Yemen. Oman Med J. 2010 Jan;25(1):41- 3. [PubMed | Full Text | DOI]
Al-Ramahi R. Patterns and attitudes of selfmedication practices and possible role of community pharmacists in Palestine. Int J Clin Pharmacol Ther. 2013 Jul;51(7):562-7. [Full Text]
Ceaser S, Wurtz R. “Leftover” antibiotics in the medicinecabinet. 2000. [PubMed | Full Text | DOI]
Crigger NJ, Holcomb L, Grogan RL, Vasquez M, Parchment C, Almendares J, et al. Development of the choices andacquisition of antibiotics model from a descriptive study ofa lay Honduran population. Int J Nurs Stud. 2004Sep;41(7):745-53. [PubMed | Full Text | DOI]
European Commission (2013) Special Eurobarometer 407 Antimicrobial resistance. TNS Opinion and Social. [Full Text]
Ong S, Nakase J, Moran GJ, Karras DJ, Kuehnert MJ, Talan DA, et al. Antibiotic use for emergency department patients with upper respiratory infections: Prescribing practices,patient expectations, and patient satisfaction. Ann Emerg Med. 2007 Sep;50(3):213-20. [PubMed | Full Text | DOI]