Cardiac surgery in a patient with Glanzmann’s thrombasthenia
Vol. 13 No. 2 (2024), Case Report
Vol. 13 No. 2 (2024)

Cardiac surgery in a patient with Glanzmann’s thrombasthenia

Case Report
Published 2024-07-21
Prabhat Khakural
Department of CTVS,Manmohan Cardiothoracic Vascular and Transplant Center
Shiwani Parajuli
Manmohan Cardiothoracic Vascular and Transplant Center, Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
Yuna Shrestha
Manmohan Cardiothoracic Vascular and Transplant Center, Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
Anil Bhattarai
Manmohan Cardiothoracic Vascular and Transplant Center, Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.

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Keywords

Atrial septal defect
Cardiac Surgery
Congenital heart disease
Glanzmann’s thrombasthenia
Platelet disorder

How to Cite

Khakural, P., Parajuli, S., Shrestha, Y., & Bhattarai, A. . (2024). Cardiac surgery in a patient with Glanzmann’s thrombasthenia. Journal of Kathmandu Medical College, 13(2). Retrieved from https://jkmc.com.np/ojs3/index.php/journal/article/view/1390
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Abstract

Cardiac surgery in patients with bleeding disorders like Glanzmann’s thrombasthenia is quite challenging because of the increased risk of postoperative bleeding resulting in higher transfusions and associated morbidity. Platelet transfusion and use of antifibrinolytic drugs help in achieving optimum haemostasis in the patients with Glanzmann’s thrombasthenia. Here, a case of six-year-old boy with Glanzmann’s thrombasthenia is reported, who underwent surgical closure of atrial septal defect and was managed with platelet transfusion and tranexamic acid. The patient recovered well without having significant bleeding in the post-operative period.

References

Ganapule A, Jain P, Abubacker FN, Korula A, Abraham A, Mammen J, et al. Surgical procedures in patients with Glanzmann's thrombasthenia: case series and literature review. Blood Coagul Fibrinolysis. 2017 Mar;28(2):171-5. [PubMed | Full Text | DOI]

Simha PP, Mohan Rao PS, Arakalgud D, Rajashekharappa R, Narasimhaih M. Perioperative management of a patient with glanzmann's thrombasthenia for mitral valve repair under cardiopulmonary bypass. Ann Card Anaesth. 2017 Oct-Dec;20(4):468-71. [Pub Med | Full Text | DOI]

Sheikh AY, Hill CC, Goodnough LT, Leung LL, Fischbein MP. Open aortic valve replacement in a patient with Glanzmann's thrombasthenia: a multidisciplinary strategy to minimize perioperative bleeding. Transfusion. 2014 Feb;54(2):300-5. [Pub Med | Full Text | DOI]

Padate B, Mansukhani D, Jijina F, Shanaz K. Acquired Glanzmann thrombasthenia: a rare disorder. J Hematopathol 2021; 14, 145–50. [Full Text | DOI]

Casati V, D'Angelo A, Barbato L, Rossi E, Grasso MA, Spagnolo S, et al. Perioperative management of a heterozygous carrier of Glanzmann's thrombasthenia submitted to coronary artery bypass grafting with cardiopulmonary bypass. Anesth Analg. 2006 Aug;103(2):309-11. [PubMed | Full Text | DOI]

Gillen J, Lazarchick J, Crawford FA Jr. Tricuspid valve replacement and ventricular septal defect repair in a patient with Glanzmann thrombasthenia. J Thorac Cardiovasc Surg. 2010 May;139(5): e114-5. [PubMed | Full Text | DOI]

Garcia-Villarreal OA, Fernández-Ceseña E, Solano-Ricardi M, Aguilar-García AL, Vega-Hernández R, Del Angel-Soto G. Unusual redo mitral valve replacement for bleeding in Glanzmann thrombasthenia. Asian Cardiovasc Thorac Ann. 2016 Jan;24(1):57-9. [PubMed | Full Text | DOI]

Truong KP, Zhang JJ, Shahid M, Goud A, Rosove M, Currier J, et al. Management of High-Grade Coronary Artery Disease and Concomitant Glanzmann Thrombasthenia. JACC Case Rep. 2021 Oct 20;3(14):1625-9. [PubMed | Full Text | DOI]